Isophorone
Health Effects
EPA's Integrated Risk Information System classifies isophorone as a Group C, possible human carcinogen. EPA's stated basis: "Based on no data in humans; limited evidence of carcinogenicity of one tumor type in one sex of one animal species as shown by an increase of preputial gland carcinomas in male rats. The apparent renal tubular cell tumor in the male rat is associated with alpha-2u-globulin, considered to be of questionable relevance to humans." The oral reference dose is 2E-1 mg/kg/day, derived from a 90-day dog feeding study in which no effects were observed at 150 mg/kg/day.
Source: EPA IRIS — Integrated Risk Information System (IRIS) (retrieved 2026-07-27)
Common Sources
- Discharge from chemical manufacturing — isophorone is used as a solvent for resins, lacquers and pesticides
- Industrial wastewater and hazardous waste sites
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Contaminant Type
Isophorone is classified as a SVOCs contaminant.
Related SVOCs Contaminants
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